Browsing Terveystieteiden tiedekunta by Title
Now showing items 1-20 of 1765
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1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) Inhibitors
(MDPI AG, 2018)We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4 ...Tieteelliset aikakauslehtiartikkelit
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24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial
(Elsevier BV, 2017)Background Nutrition is an important modifiable risk factor in Alzheimer's disease. Previous trials of the multinutrient Fortasyn Connect showed benefits in mild Alzheimer's disease dementia. LipiDiDiet investigated the ...info:eu-repo/semantics/article
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25 years of advances in the definition, classification and treatment of status epilepticus
(Elsevier BV, 2017)Purpose Status epilepticus (SE) requires not only urgent symptomatic treatment with antiepileptic drugs but also rapid identification and treatment of its cause. This narrative review summarizes the most important advances ...info:eu-repo/semantics/article
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30-Day Recurrence, Readmission Rate and Clinical Outcome After Emergency Lumbar Discectomy
(Ovid Technologies (Wolters Kluwer Health), 2020)Study Design. A retrospective cohort study. Objective. To investigate the 30-day recurrence rate after emergency lumbar discectomy. Secondary aims were to investigate the factors affecting the 30-day recurrence and ...Tieteelliset aikakauslehtiartikkelit
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3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases
(Elsevier BV, 2018)Neurodegenerative disorders have an enormous impact on society and healthcare budgets. There has been a high degree of failure in many recent clinical trials for disease-modifying therapeutics. A major factor in this failure ...Tieteelliset aikakauslehtiartikkelit
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5 years of successful inducible transgene expression following locoregional AAV delivery in nonhuman primates with no detectable immunity
(Mary Ann Liebert Inc, 2019)Anti-transgene immune responses elicited after intramuscular (i.m.) delivery of recombinant adeno-associated virus (rAAV) have been shown to hamper long-term transgene expression in large-animal models of rAAV-mediated ...Tieteelliset aikakauslehtiartikkelit
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5-hydroxytryptamine in migraine: the puzzling role of ionotropic 5-HT3 receptor in the context of established therapeutic effect of metabotropic 5-HT1 subtypes
(Wiley, 2021)5-hydroxytryptamine (5-HT; serotonin) is traditionally considered as a key mediator implicated in migraine. Multiple 5-HT receptor subtypes contribute to a variety of region-specific functional effects. The raphé nuclei ...Tieteelliset aikakauslehtiartikkelit
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A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children: the PANIC study
(Springer Science and Business Media LLC, 2020)Aims/hypothesis We studied for the first time the long-term effects of a combined physical activity and dietary intervention on insulin resistance and fasting plasma glucose in a general population of predominantly ...Tieteelliset aikakauslehtiartikkelit
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A Bayesian network model to identify the associations between the use of seclusion in psychiatric care and nursing managers' attitudes towards containment methods
(John Wiley & Sons Ltd, 2021)4.1 Introduction The use of seclusion in psychiatric care should be reduced. The relationship between nursing management or nursing managers' attitudes and the use of seclusion has not been investigated. 4.2 Aim To ...Tieteelliset aikakauslehtiartikkelit
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A century of trends in adult human height
(eLife Sciences Organisation, Ltd., 2016)Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height ...info:eu-repo/semantics/article
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A cross-sectional study of vitamin D levels in a large cohort of patients with rheumatic diseases
(Springer Nature, 2018)The objective of this study is to examine 25-hydroxyvitamin D [25(OH)D] (D-25) levels and associations with patient- and disease-related factors in rheumatic diseases. This is a register-based study of D-25 levels in adult ...info:eu-repo/semantics/article
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A dynamic theory of economics: What are the market forces?
(, 2019)The main weakness in the neoclassical theory of economics is its static nature. By a static model one cannot explain observed time paths of economic quantities, like the flows of production of firms, the flows of consumption ...Tieteelliset aikakauslehtiartikkelit
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A Liftless Intervention to Prevent Preterm Birth and Low Birthweight Among Pregnant Ghanaian Women: Protocol of a Stepped-Wedge Cluster Randomized Controlled Trial
(JMIR Publications Inc., 2018)Background: Preterm birth (PTB) is a leading cause of infant morbidity and mortality worldwide. Every year, 20 million babies are born with low birthweight (LBW), about 96% of which occur in low-income countries. Despite ...Tieteelliset aikakauslehtiartikkelit
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A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology
(Elsevier BV, 2019)No single-omic approach completely elucidates the multitude of alterations taking place in Alzheimer's disease (AD). Here, we coupled transcriptomic and phosphoproteomic approaches to determine the temporal sequence of ...Tieteelliset aikakauslehtiartikkelit
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A multiparametric classification system for lesions detected by breast magnetic resonance imaging
(Elsevier BV, 2020)Background To validate a new categorisation scheme for suspicious breast lesions according to the well-defined Breast Imaging Reporting and Data System (BI-RADS) magnetic resonance imaging (MRI) lexicon descriptors, ...Tieteelliset aikakauslehtiartikkelit
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A narrative of recovery in forensic hospitals
(Elsevier Inc., 2024)Aim Concerns about the applicability of recovery orientation to forensic care have surfaced due to the traditionally restrictive practices associated with forensic institutions. We interviewed 19 experts-by-experience and ...
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A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants
(Springer Nature America, Inc, 2018)Preeclampsia (PE) is a complex pregnancy disorder. It is not extensively known how the metabolic alterations of PE women contribute to the metabolism of newborn. We applied liquid chromatography-mass spectrometry (LC-MS) ...Tieteelliset aikakauslehtiartikkelit
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A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs
(Springer Nature, 2016)Background Attention deficit hyperactivity disorder (ADHD) is a prevalent and multifactorial neuropsychiatric disorder in the human population worldwide. Complex etiology and clinical heterogeneity have challenged the ...info:eu-repo/semantics/article
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A participatory arts programme – Shared experience for family caregivers and care recipients
(John Wiley & Sons Ltd, 2023)Aim This study aimed to describe family caregivers of older people's experiences of participatory art interventions, including music, dance and visual arts. Design A descriptive qualitative study. Methods Thematic ...
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A peer-support lifestyle intervention for preventing type 2 diabetes in India: A cluster-randomized controlled trial of the Kerala Diabetes Prevention Program.
(Public Library of Science (PLoS), 2018)Background The major efficacy trials on diabetes prevention have used resource-intensive approaches to identify high-risk individuals and deliver lifestyle interventions. Such strategies are not feasible for wider ...Tieteelliset aikakauslehtiartikkelit