Browsing Terveystieteiden tiedekunta by Issue Date

Now showing items 1-20 of 1737

    • AMPA receptors in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study 

      Kärkkäinen, Olli; Kupila, Jukka; Häkkinen, Merja; Laukkanen, Virpi; Tupala, Erkki; Kautiainen, Hannu; Tiihonen, Jari; Storvik, Markus (Elsevier BV, 2013)
      Dysfunction of the brain glutamate system has been associated with alcoholism. Ionotropic glutamatergic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs) play an important role in both neurotransmission ...
      article

    • Endogenous cannabinoids in amygdala and hippocampus in post-mortem brains of Cloninger type 1 and 2 alcoholics 

      Kärkkäinen, Olli K; Lehtonen, Marko; Laukkanen, Virpi; Tupala, Erkki; Hyytiä, Petri; Kautiainen, Hannu; Tiihonen, Jari; Callaway, JC; Storvik, Markus (Elsevier BV, 2013)
      Accumulating evidence continues to link certain aspects of the endogenous cannabinoid (EC) system with alcohol dependence, negative-reinforcement learning, and the modulation of stress responses. Specific alterations in ...
      article

    • Lower [3H]Citalopram Binding in Brain Areas Related to Social Cognition in Alcoholics 

      Kärkkäinen, Olli; Laukkanen, Virpi; Haukijärvi, Tuija; Kautiainen, Hannu; Tiihonen, Jari; Storvik, Markus (Elsevier BV, 2014)
      In the present study, putative alterations in the serotonin transporter density were evaluated in anterior and posterior insula, posterior cingulate cortex, dorsolateral and dorsomedial prefrontal cortex, hippocampus, ...
      article

    • SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin 

      Toropainen, Sari; Malinen, Marjo; Kaikkonen, Sanna; Jääskeläinen, Tiina; Sahu, Biswajyoti; Jänne, Olli A; Palvimo, Jorma J (Oxford University Press on behalf of Nucleic Acids Research., 2014)
      Androgen receptor (AR) is a ligand-activated transcription factor that plays a central role in the development and growth of prostate carcinoma. PIAS1 is an AR- and SUMO-interacting protein and a putative transcriptional ...
      info:eu-repo/semantics/article

    • Validation of protein carbonyl measurement: A multi-centre 

      Augustyniak, Edyta; Adam, Aisha; Wojdyla, Katarzyna; Rogowska-Wrzesinska, Adelina; Willetts, Rachel; Korkmaz, Ayhan; Atalay, Mustafa; Weber, Daniela; Grune, Tilman; Borsa, Claudia; Gradinaru, Daniela; Chand Bollineni, Ravi; Fedorova, Maria; Griffiths, Helen R (Elsevier BV, 2014)
      Protein carbonyls are widely analysed as a measure of protein oxidation. Several different methods exist for their determination. A previous study had described orders of magnitude variance that existed when protein carbonyls ...
      info:eu-repo/semantics/article

    • Global SUMOylation on active chromatin is an acute heat stress response restricting transcription 

      Niskanen, Einari; Malinen, Marjo; Sutinen, Päivi; Toropainen, Sari; Paakinaho, Ville; Vihervaara, Anniina; Joutsen, Jenny; Kaikkonen, Minna U; Sistonen, Lea; Palvimo, Jorma J (BioMed Central, 2015)
      Background Cells have developed many ways to cope with external stress. One distinctive feature in acute proteotoxic stresses, such as heat shock (HS), is rapid post-translational modification of proteins by SUMOs (small ...
      info:eu-repo/semantics/article

    • Secular trends affect timing of emergence of permanent teeth 

      Eskeli, Ritva; Lösönen, Matias; Ikävalko, Tiina; Myllykangas, Riitta; Lakka, Timo; Laine-Alava, Maija T (The Angle Orthodontist (EH Angle Education & Research Foundation), 2015)
      Objective:  To examine the expression of possible secular trend in timing of the emergence of permanent teeth in Finnish children over the past few decades, considering the differences between genders. Materials and ...
      info:eu-repo/semantics/article

    • Diagnosis of Knee Osteochondral Lesions With Ultrasound 

      Penttilä, Pekko; Liukkonen, Jukka; Joukainen, Antti; Virén, Tuomas; Jurvelin, Jukka S; Töyräs, Juha; Kröger, Heikki (Elsevier BV, 2015)
      Evaluation of articular cartilage and subchondral bone is essential in the diagnosis of joint diseases and injuries. Interobserver and intraobserver reproducibilities of arthroscopic grading are only poor to moderate. Thus, ...
      info:eu-repo/semantics/article

    • The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study 

      Winkler, Thomas W; Justice, Anne E; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F; Chu, Su; Czajkowski, Jacek; Esko, Tõnu; Fall, Tove; Yaluri, Alena (Public Library of Science (PLoS), 2015)
      Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and ...
      info:eu-repo/semantics/article

    • Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network 

      Heinäniemi, Merja Hannele; Maria Pires Pacheco; Elisabeth John; Tony Kaoma; Nathalie Nicot; Laurent Vallar; Jean-Luc Bueb; Lasse Sinkkonen; Thomas Sauter (BioMed Central, 2015)
      Background The reconstruction of context-specific metabolic models from easily and reliably measurable features such as transcriptomics data will be increasingly important in research and medicine. Current reconstruction ...
      info:eu-repo/semantics/article

    • Experiential Thinking in Creationism - A Textual Analysis 

      Nieminen, Petteri; Ryökäs, Esko; Mustonen, Anne-Mari (PLOS, 2015)
      Creationism is a religiously motivated worldview in denial of biological evolution that has been very resistant to change. We performed a textual analysis by examining creationist and pro-evolutionary texts for aspects of ...
      info:eu-repo/semantics/article

    • Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation 

      Ziyatdinova, Sofya; Viswanathan, Jayashree; Hiltunen, Mikko; Tanila, Heikki; Pitkänen, Asla (Elsevier BV, 2015)
      Patients with Alzheimer´s disease are at increased risk for unprovoked seizures and epilepsy compared with age-matched controls. Experimental evidence suggests that neuronal hyperexcitability and epilepsy can be triggered ...
      info:eu-repo/semantics/article

    • The Nordic diet and cognition – The DR's EXTRA Study 

      Männikkö, Reija; Komulainen, Pirjo; Schwab, Ursula; Heikkilä, Harri M; Savonen, Kai; Hassinen, Maija; Hänninen, Tuomo; Kivipelto, Miia; Rauramaa, Rainer (Cambridge University Press (CUP), 2015)
      The rapid increase in the prevalence of dementia associated with ageing populations has stimulated interest in identifying modifiable lifestyle factors that could prevent cognitive impairment. One such potential preventive ...
      info:eu-repo/semantics/article

    • Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies 

      Moilanen, Anu-Maarit; Riikonen, Reetta; Oksala, Riikka; Ravanti, Laura; Aho, Eija; Wohlfahrt, Gerd; Nykänen, Pirjo S; Törmäkangas, Olli P; Palvimo, Jorma J; Kallio, Pekka J (Nature Publishing Group, 2015)
      Activation of androgen receptor (AR) is crucial for prostate cancer growth. Remarkably, also castration-resistant prostate cancer (CRPC) is dependent on functional AR, and several mechanisms have been proposed to explain ...
      info:eu-repo/semantics/article

    • IgE Reactivity of the Dog Lipocalin Allergen Can f 4 and the Development of a Sandwich ELISA for Its Quantification 

      Rytkönen-Nissinen, Marja; Saarelainen, Soili; Randell, Jukka; Häyrinen, Jukka; Kalkkinen, Nisse; Virtanen, Tuomas (The Korean Academy of Asthma, Allergy and Clinical Immunology and The Korean Academy of Pediatric Al, 2015)
      Purpose Divergent results on the IgE reactivity of dog-allergic subjects to Can f 4 have been reported. The aim of this study was to evaluate the significance of Can f 4 in dog allergy and to develop an immunochemical ...
      article

    • Biological interpretation of genome-wide association studies using predicted gene functions 

      Pers, Tune H; Karjalainen, Juha M; Chan, Yingleong; Westra, Harm-Jan; Wood, Andrew R; Yang, Jian; Lui, Julian C; Vedantam, Sailaja; Gustafsson, Stefan; Esko, Tonu; Frayling, Tim; Speliotes, Elizabeth K; Boehnke, Michael; Raychaudhuri, Soumya; Fehrmann, Rudolf S. N; Hirschhorn, Joel N; Franke, Lude; Kuusisto, Johanna (Nature Publishing Group, 2015)
      The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions ...
      info:eu-repo/semantics/article

    • Vitamin D receptor signaling and its therapeutic implications: Genome-wide and structural view 1 

      Carlberg, Carsten; Molnár, Ferdinand (Canadian Science Publishing, 2015)
      Vitamin D3 is one of the few natural compounds that has, via its metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and the transcription factor vitamin D receptor (VDR), a direct effect on gene regulation. For efficiently ...
      info:eu-repo/semantics/article

    • Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia 

      Koistinen, Ville; Kärnä, Riikka; Koistinen, Arto; Arjonen, Antti; Tammi, Markku; Rilla, Kirsi (Elsevier BV, 2015)
      Previous studies have shown that overexpression of enzymatically active GFP-HAS induces the growth of long, slender protrusions that share many features of both filopodia and microvilli. These protrusions are dependent on ...
      info:eu-repo/semantics/article

    • Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase 

      Navia-Paldanius, Dina; Aaltonen, Niina; Lehtonen, Marko; Savinainen, Juha R; Taschler, Ulrike; Radner, Franz P.W.; Zimmermann, Robert; Laitinen, Jarmo T (Elsevier BV, 2015)
      In mammalian brain, monoacylglycerol lipase (MAGL) is the primary enzyme responsible for terminating signaling function of the endocannabinoid 2-arachidonoylglycerol (2-AG). Previous in vivo studies with mice indicate that ...
      info:eu-repo/semantics/article

    • Reorganization of Nuclear Pore Complexes and the Lamina in Late-Stage Parvovirus Infection 

      Mäntylä, Elina; Niskanen, Einari A; Ihalainen, Teemu O; Vihinen-Ranta, Maija (American Society for Microbiology, 2015)
      Canine parvovirus (CPV) infection induces reorganization of nuclear structures. Our studies indicated that late-stage infection induces accumulation of nuclear pore complexes (NPCs) and lamin B1 concomitantly with a decrease ...
      info:eu-repo/semantics/article